Aggressive behaviour of Hodgkin's-like lymphoma in a domestic ferret

A 3-year-old castrated male ferret was suspected to have lymphoma based on a markedly enlarged mesenteric lymph node. Hodgkin’s-like (HLL) because numerous Reed-Sternberg-like cells were observed in the fine-needle aspiration biopsy of In post-mortem histopathology, neoplastic invasively proliferated not only nodes, but also liver and spleen. Immunohistochemically, most positive for vimentin BLA-36, weakly CD20, negative Pax5, CD79a, CD3, CD45, Iba-1, demonstrating similarity human Hodgkin’s (HL). addition, prominent programmed cell death protein 1 (PD-1) expression at sites showing malignant tumour proliferation. HLL non-human beings can be morphologically immunophenotypically similar HL, prognosis clinical outcome may differ. This is first study analysing PD-1 ferret, suggesting that novel diagnostic prognostic factor manner humans.